Asymptomatic CNS demyelination related to TNF-α inhibitor therapy
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چکیده
منابع مشابه
Asymptomatic CNS demyelination related to TNF-α inhibitor therapy
Tumor necrosis factor (TNF)–a inhibitors are a subtype of disease-modifying antirheumatic drugs that have revolutionized the treatment of rheumatologic and gastrointestinal disorders. TNF-a is a cytokine with a complex role in immune system regulation and maintenance of self-tolerance. Despite their clinical benefit in rheumatologic conditions, TNF-a inhibitors have been implicated in the devel...
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Tumor necrosis factor-α (TNF-α) blockers are a popular therapeutic choice in a number of inflammatory diseases. Thus far, five TNF- α blockers have been approved for clinical use (etanercept, infliximab, adalimumab, golimumab. and certolizumab). Despite being considered relatively safe, serious side effects associated with immune suppression have been reported, including central and peripheral ...
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As part of a prospective study on the safety of TNF-α inhibitor therapy after screening for and treatment of latent tuberculosis infection (LTBI), we report two patients who developed active tuberculosis (TB) infection during TNF-α inhibitor therapy, despite negative screening for LTBI. The clinical history is suggestive of a primary infection acquired during travelling to TB-endemic countries....
متن کاملPattern of demyelination occurring during anti-TNF-α therapy: a French national survey.
OBJECTIVE To determine the pattern of demyelinating disorders (DDs) occurring during anti-TNF-α therapy. METHODS Between June 2005 and April 2008, 1800 French rheumatologists and internists were contacted to report cases of DDs occurring in patients treated with anti-TNF-α. RESULTS After a median of 10.2 (1.5-39.9) months of treatment, 33 patients developed DDs: 22 had CNS and 11 peripheral...
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A 43-year-old woman with a history of psoriasis vulgaris was admitted for nephrotic syndrome that had started 6 months before. Renal biopsy revealed membranous glomerulonephritis (MGN). She did not receive any therapy for MGN. Two months later she started therapy for psoriasis with adalimumab, which resulted in disappearance of psoriatic skin lesions with progressive reduction of 24h proteinuri...
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ژورنال
عنوان ژورنال: Neurology - Neuroimmunology Neuroinflammation
سال: 2016
ISSN: 2332-7812
DOI: 10.1212/nxi.0000000000000298